ISDA: 9VTF

Deposition Date 2025-07-10

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9VTF

Keywords:

BIOSYNTHETIC PROTEIN

Title:

Structural basis for the inhibition of cystathionine-b-synthase by isoflurane

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.03 Å

R-Value Free:

0.26

R-Value Work:

0.21

R-Value Observed:

0.22

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cystathionine beta-synthase
Gene (Uniprot):CBS
Chain IDs:A, B, C, D
Chain Length:573
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P35520 Pfam ID:PF00291, PF00571 EC:4.2.1.22

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
LLP	A	LYS	modified residue

Ligand Molecules

4LE

HEM

Primary Citation

Structural basis for the inhibition of cystathionine-b-synthase by isoflurane and its role in anaesthesia-induced social dysfunction in mice

Xu, K.Show

British Journal of Anaesthesia 3 746 758 (2025)

PMID: 39603853 DOI: 10.1016/j.bja.2024.09.023

Primary Citation of related structures

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