ISDA: 9VT4

Deposition Date 2025-07-09

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9VT4

Keywords:

MEMBRANE PROTEIN

Title:

EBOV GP/BA2-VHH complex

Biological Source:

Source Organism(s):

Zaire ebolavirus (Taxon ID: 186538)
Ebola virus - Gabon (1994-1997) (Taxon ID: 128947)
Vicugna pacos (Taxon ID: 30538)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.96 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Envelope glycoprotein,GP1
Gene (Uniprot):GP, GP
Chain IDs:A, D (auth: C), G (auth: E)
Chain Length:315
Number of Molecules:3
Biological Source:Zaire ebolavirus, Ebola virus - Gabon (1994-1997)

UniProt ID:G8DB49,O11457

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Envelope glycoprotein
Gene (Uniprot):GP
Chain IDs:B, E (auth: D), H (auth: F)
Chain Length:156
Number of Molecules:3
Biological Source:Zaire ebolavirus

UniProt ID:A0A5J6EDK7

Protein Blast

Polymer Type:polypeptide(L)
Molecule:nanobody BA2
Chain IDs:C (auth: G), F (auth: H), I
Chain Length:128
Number of Molecules:3
Biological Source:Vicugna pacos

Ligand Molecules

Primary Citation

A highly potent nanobody-based bispecific therapeutic provides broad-spectrum protection against ebolavirus.

Wang, M, Zhang, X, Li, W, Yao, Y, Li, E, Zhang, B, Zhou, J, Liu, S, Gao, Y, Zhu, Z, Zhu, L, Liu, M, Hu, J, Peng, C, Li, F, Chen, M, Liu, H, Yao, C, Shang, Y, Yan, F, Gong, P, Jin, T, Chiu, S.Show

Nat Commun 17 ? ? (2026)

PMID: 41839884 DOI: 10.1038/s41467-026-70464-6

Primary Citation of related structures

Feedback Form