ISDA: 9VT2

Deposition Date 2025-07-09

Release Date 2026-09-30

Last Version Date 2026-09-30

Entry Detail

PDB ID:

9VT2

Keywords:

TRANSPORT PROTEIN

Title:

Structure of Cdr1 with Fluconazole at the middle site

Biological Source:

Source Organism(s):

Candida albicans SC5314 (Taxon ID: 237561)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.79 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Pleiotropic ABC efflux transp
Gene (Uniprot):CDR1
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Candida albicans SC5314

UniProt ID:Q5ANA3 Pfam ID:PF14510, PF00005, PF01061, PF06422

Ligand Molecules

TPF

Primary Citation

Cryo-EM structures of Cdr1 reveal snapshots of substrate transport and diverse inhibitor recognition.

Wang, Z, Yang, S, Zhang, B, Jiang, H, Li, Y, Gao, R, Wang, Y, Fan, F, Dong, L, Qiu, J, Li, X, Zhou, Y, Murchie, A.I.H, Yu, X.Show

Sci Adv 12 eaef7706 eaef7706 (2026)

PMID: 42664345 DOI: 10.1126/sciadv.aef7706

Primary Citation of related structures

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