ISDA: 9VQ5

Deposition Date 2025-07-04

Release Date 2026-07-08

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9VQ5

Keywords:

OXIDOREDUCTASE

Title:

Crystal structure of Peroxiredoxin I in complex with SAC

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.50 Å

R-Value Free:

0.19

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Peroxiredoxin-1
Gene (Uniprot):PRDX1
Mutagens:C52S/C83S
Chain IDs:A, B
Chain Length:175
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q06830 Pfam ID:PF00578, PF10417 EC:1.11.1.24

Ligand Molecules

A1ES6

Primary Citation

Design and evaluation of peroxiredoxin 1 agonist based on scaffold hopping of salvianolic acids and combinatorial click chemistry.

Zhu, Y.Y, Chen, S, Zhang, S.N, Zhu, Y.S, Liang, J.Y, Wang, Z.Y, Wang, X.M, Liu, J.J, Liu, P.F, Li, Z.H, Xiao, W.L, Xu, H, Luo, C, Xiong, H, Zhang, H.Show

Acta Pharmacol.Sin. 47 1965 1979 (2026)

PMID: 41803461 DOI: 10.1038/s41401-026-01765-1

Primary Citation of related structures

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