9VPQ image
Deposition Date 2025-07-03
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9VPQ
Keywords:
TRANSFERASE
Title:
Crystal structure of METTL9 in complex with compound 15k
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.28 Å
R-Value Free:
0.27
R-Value Work:
0.21
R-Value Observed:
0.22
Space Group:
C 1 2 1
9VPQ validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein-L-histidine N-pros-me
Gene (Uniprot):METTL9
Mutagens:L95A, F96A, L99A, F103A, V107A, F111A
Chain IDs:A, C (auth: B)
Chain Length:274
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q9H1A3 Pfam ID:PF05219
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Zinc transporter ZIP5
Gene (Uniprot):SLC39A5
Chain IDs:B (auth: C), D
Chain Length:12
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q6ZMH5
Ligand Molecules
A1ES7
Primary Citation
Discovery of a Potent and Selective Cell-Active Inhibitor of Histidine-N1 Methyltransferase METTL9.
Angew. Chem. Int. Ed. Engl. ? e3642560 e3642560 (2026)
PMID: 41870122 DOI: 10.1002/anie.3642560
Primary Citation of related structures
9VPQ
Feedback Form
Name
Email
Institute
Feedback