9VPM image
Deposition Date 2025-07-03
Release Date 2026-07-08
Last Version Date 2026-07-08
Entry Detail
PDB ID:
9VPM
Keywords:
STRUCTURAL PROTEIN
Title:
AMG986-bound APLNR dimer in active state 2a in complex with Gi-protein
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Spodoptera frugiperda, Trichoplusia ni
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
4.00 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9VPM validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Chain IDs:B (auth: A)
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P63096 Pfam ID:PF00503 EC:3.6.5.-
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:C (auth: B)
Chain Length:345
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62873 Pfam ID:PF25391
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:A (auth: G)
Chain Length:70
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P59768 Pfam ID:PF00631
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Apelin receptor
Gene (Uniprot):APLNR
Chain IDs:E (auth: R), F (auth: Q)
Chain Length:380
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P35414 Pfam ID:PF00001
Protein Blast
Polymer Type:polypeptide(L)
Molecule:single Fab chain(scFv16)
Chain IDs:D (auth: S)
Chain Length:250
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
NA
Primary Citation
AMG986-bound APLNR dimer in active state 2a in complex with Gi-protein
To Be Published ? ? ? (?)
Primary Citation of related structures
9VPM
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