ISDA: 9VPG

Deposition Date 2025-07-03

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

9VPG

Keywords:

TRANSPORT PROTEIN

Title:

Cryo-EM structure of human urate transporter GLUT9 bound to a selective inhibitor SG4

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.14 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Solute carrier family 2, faci
Gene (Uniprot):SLC2A9
Chain IDs:A
Chain Length:582
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9NRM0 Pfam ID:PF00083

Ligand Molecules

A1ETZ

Primary Citation

Selective GLUT9 inhibitors for hyperuricemia via intestinal mechanism

Zhao, Z, Sun, Z, Shen, Z, Zheng, F, Zhang, X, Luo, Z, He, Y, Xu, Y, Wu, Z, Ke, J, Li, J, Wu, T, Zhang, Q, Tian, Y, Pan, X, Pang, J, Chen, J.Show

Acta Pharm Sin B ? ? ? (2026)

DOI: 10.1016/j.apsb.2026.03.011

Primary Citation of related structures

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