9VOZ image
Deposition Date 2025-07-02
Release Date 2026-07-15
Last Version Date 2026-07-15
Entry Detail
PDB ID:
9VOZ
Keywords:
ONCOPROTEIN
Title:
EGFR T790M/L858R mutant in complex with covalent inhibitor TAS-121
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.83 Å
R-Value Free:
0.24
R-Value Work:
0.20
R-Value Observed:
0.21
Space Group:
I 2 3
9VOZ validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Epidermal growth factor recep
Gene (Uniprot):EGFR
Chain IDs:A
Chain Length:330
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P00533 Pfam ID:PF07714 EC:2.7.10.1
Ligand Molecules
A1MAP
Primary Citation
Discovery of TAS-121 , as a Novel, Potent, Mutant Selective, Orally Available Covalent Tyrosine Kinase Inhibitor for EGFR Mutations Including T790M in Non-Small Cell Lung Cancer
To Be Published ? ? ? (?)
Primary Citation of related structures
9VOZ
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