9VOY image
Deposition Date 2025-07-02
Release Date 2026-07-15
Last Version Date 2026-07-15
Entry Detail
PDB ID:
9VOY
Keywords:
ONCOPROTEIN
Title:
EGFR T790M/L858R mutant in complex with covalent inhibitor TAS6417
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.67 Å
R-Value Free:
0.23
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
I 2 3
9VOY validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Epidermal growth factor recep
Gene (Uniprot):EGFR
Chain IDs:A
Chain Length:330
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P00533 Pfam ID:PF07714 EC:2.7.10.1
Ligand Molecules
CL
X9H
Primary Citation
Discovery of Zipalertinib (TAS6417) as a Novel, Potent, Mutant Selective, and Orally Available Covalent EGFR Inhibitor Targeting EGFR Exon 20 Insertion Mutations in Non-Small Cell Lung Cancer
To Be Published ? ? ? (?)
Primary Citation of related structures
9VOY
Feedback Form
Name
Email
Institute
Feedback