ISDA: 9VOX

Deposition Date 2025-07-02

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9VOX

Keywords:

ONCOPROTEIN

Title:

EGFR T790M/L858R mutant in complex with covalent inhibitor TAS-2913

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.69 Å

R-Value Free:

0.25

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

I 2 3

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Epidermal growth factor recep
Gene (Uniprot):EGFR
Chain IDs:A
Chain Length:330
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P00533 Pfam ID:PF07714 EC:2.7.10.1

Ligand Molecules

A1MAO

Primary Citation

Discovery of TAS-121 , as a Novel, Potent, Mutant Selective, Orally Available Covalent Tyrosine Kinase Inhibitor for EGFR Mutations Including T790M in Non-Small Cell Lung Cancer

Uno, T, Suzuki, T.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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