9VL2 image
Deposition Date 2025-06-24
Release Date 2026-05-27
Last Version Date 2026-05-27
Entry Detail
PDB ID:
9VL2
Keywords:
IMMUNE SYSTEM
Title:
Structure of CD33 complexed with its mAb-10C8
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens, Cricetulus griseus
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.18 Å
R-Value Free:
0.25
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
P 1
9VL2 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Myeloid cell surface antigen
Gene (Uniprot):CD33
Chain IDs:A, D
Chain Length:214
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P20138 Pfam ID:PF07686, PF00047
Protein Blast
Polymer Type:polypeptide(L)
Molecule:light chain of Fab-10C8
Chain IDs:B, E
Chain Length:213
Number of Molecules:2
Biological Source:Homo sapiens
Protein Blast
Polymer Type:polypeptide(L)
Molecule:heavy chain of Fab-10C8
Chain IDs:C, F
Chain Length:220
Number of Molecules:2
Biological Source:Homo sapiens
Ligand Molecules
NAG
Primary Citation
Crystal structure of the CD33/Fab-10C8 complex elucidates the mechanism of antibody antagonism in HBV-induced immunosuppression
J.Biomed.Sci. ? ? ? (2026)
DOI: 10.1186/s12929-026-01248-9
Primary Citation of related structures
9VL2
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