ISDA: 9VH4

Deposition Date 2025-06-16

Release Date 2026-06-24

Last Version Date 2026-06-24

Entry Detail

PDB ID:

9VH4

Keywords:

VIRAL PROTEIN

Title:

Cryo EM structure of hemagglutinin from Puerto Rico/8/1934 (H1N1) in complex with a single domain antibody

Biological Source:

Source Organism(s):

Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) (Taxon ID: 211044)
Vicugna pacos (Taxon ID: 30538)

Expression System(s):

Mammalian expression vector flag-mcs-pcdna3.1, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.80 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Hemagglutinin HA1 chain
Gene (Uniprot):HA
Chain IDs:A, F (auth: D), G
Chain Length:322
Number of Molecules:3
Biological Source:Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)

UniProt ID:P03452 Pfam ID:PF00509

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Hemagglutinin
Gene (Uniprot):HA
Chain IDs:B, H (auth: E), I (auth: H)
Chain Length:175
Number of Molecules:3
Biological Source:Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)

UniProt ID:P03452 Pfam ID:PF00509

Protein Blast

Polymer Type:polypeptide(L)
Molecule:nanobody
Chain IDs:C, D (auth: F), E (auth: I)
Chain Length:119
Number of Molecules:3
Biological Source:Vicugna pacos

Ligand Molecules

Primary Citation

Inhalable and broadly neutralizing single-domain antibodies targeting influenza A hemagglutinin

Huang, K.K, Lv, M.W, Kong, Y, Wang, M.K, Ma, X.J, Xu, Q.Y, Zhu, X.Y, Li, W.X, Ying, T.L, Yang, Z.L, Wu, Y.L.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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