ISDA: 9VGQ

Deposition Date 2025-06-14

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9VGQ

Keywords:

OXIDOREDUCTASE

Title:

Crystal structure of the cytochrome P450 RosC in complexed with 20-deoxo-20-dihydrorosamicin

Biological Source:

Source Organism(s):

Micromonospora rosaria (Taxon ID: 47874)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.30 Å

R-Value Free:

0.25

R-Value Work:

0.19

R-Value Observed:

0.20

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome P450
Gene (Uniprot):rosC
Chain IDs:A, B
Chain Length:388
Number of Molecules:2
Biological Source:Micromonospora rosaria

UniProt ID:I7HHD0

Ligand Molecules

A1MAJ

ACT

EDO

HEM

MLT

Primary Citation

Enzyme engineering of cytochrome P450 RosC provides mechanistic insights into factors controlling iterative oxidation.

Iizaka, Y, Suzuki, H, Sasa, N, Ishiuchi, K, Kumakiri, Y, Kawasaki, H, Sato, H, Fujimoto, K, Noguchi, S, Anzai, Y.Show

Appl. Microbiol. Biotechnol. 109 264 264 (2025)

PMID: 41366128 DOI: 10.1007/s00253-025-13648-2

Primary Citation of related structures

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