9VFA image
Deposition Date 2025-06-10
Release Date 2026-06-17
Last Version Date 2026-06-17
Entry Detail
PDB ID:
9VFA
Keywords:
TRANSFERASE
Title:
GSTM1 in complex with GSH and bithionol
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.15 Å
R-Value Free:
0.25
R-Value Work:
0.22
R-Value Observed:
0.22
Space Group:
P 21 21 21
9VFA validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Glutathione S-transferase Mu
Gene (Uniprot):GSTM1
Mutagens:D537G, T539C, V540E, K541Q, Y1022C, 377-413 deletion
Chain IDs:A, B, C, D
Chain Length:218
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P09488 Pfam ID:PF02798, PF00043 EC:2.5.1.18
Ligand Molecules
B1T
GOL
GSH
Primary Citation
Bithionol Targets GSTs to Increase Oxidative Stress and Enhance Doxorubicin Efficacy
To Be Published ? ? ? (?)
Primary Citation of related structures
9VF9
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