ISDA: 9VEE

Deposition Date 2025-06-09

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9VEE

Keywords:

MEMBRANE PROTEIN

Title:

The cryo-EM structure of human Piezo2-MDFIC2 complex (composite map)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Aequorea victoria (Taxon ID: 6100)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.36 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Piezo-type mechanosensitive i
Chain IDs:A, C (auth: B), E (auth: C)
Chain Length:3020
Number of Molecules:3
Biological Source:Homo sapiens, Aequorea victoria

Polymer Type:polypeptide(L)
Molecule:MyoD family inhibitor domain-
Chain IDs:B (auth: F), D, F (auth: E)
Chain Length:211
Number of Molecules:3
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

MDFIC2 is a sensory neuron-specific PIEZO channel auxiliary subunit

Zhang, Y, Dai, F.Show

Proc.Natl.Acad.Sci.USA ? ? ? (2026)

Primary Citation of related structures

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