ISDA: 9VDI

Deposition Date 2025-06-08

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9VDI

Keywords:

RECOMBINATION

Title:

Crystal structure of the recombinant A1-antitrypsin F51L/M351V/M358V triple mutant

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.60 Å

R-Value Free:

0.25

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Alpha-1-antitrypsin
Gene (Uniprot):SERPINA1
Mutagens:F51L,M351V,M358V
Chain IDs:A, B
Chain Length:372
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P01009 Pfam ID:PF00079

Ligand Molecules

Primary Citation

Development of a chemically modified recombinant alpha 1-antitrypsin mutant expressed in E. coli for therapeutic applications.

Yang, D, Wang, B, Wang, X, Zhu, W, Lan, T, Lin, M, Wang, Y, Wei, X, Li, L, Lin, X.Show

Int. J. Biol. Macromol. 339 149972 149972 (2026)

PMID: 41475648 DOI: 10.1016/j.ijbiomac.2025.149972

Primary Citation of related structures

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