ISDA: 9V9H

Deposition Date 2025-05-30

Release Date 2026-06-10

Last Version Date 2026-06-10

Entry Detail

PDB ID:

9V9H

Keywords:

GENE REGULATION

Title:

Cryo-EM structure of the cPRC1-di-nucleosome (tight) complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

4.50 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H3.1
Gene (Uniprot):H3C1, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3C10, H3C11, H3C12
Chain IDs:A, E, K, M
Chain Length:136
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P68431 Pfam ID:PF00125

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H4
Gene (Uniprot):H4C1, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16
Chain IDs:B, F, Q, R
Chain Length:103
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P62805 Pfam ID:PF15511

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H2A type 1-H
Gene (Uniprot):H2AC12
Chain IDs:C, G, L, O
Chain Length:128
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q96KK5 Pfam ID:PF00125, PF16211

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H2B type 1-C/E/F/G/I
Gene (Uniprot):H2BC4, H2BC6, H2BC7, H2BC8, H2BC10
Chain IDs:D, H, N, P
Chain Length:126
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P62807 Pfam ID:PF00125

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (276-MER)
Chain IDs:I
Chain Length:276
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (276-MER)
Chain IDs:J
Chain Length:276
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Polycomb complex protein BMI-
Gene (Uniprot):BMI1
Chain IDs:S, U
Chain Length:326
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P35226 Pfam ID:PF13923, PF16207

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase R
Gene (Uniprot):RNF2
Chain IDs:T, V
Chain Length:336
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q99496 Pfam ID:PF13923, PF16207 EC:2.3.2.27

Ligand Molecules

Primary Citation

Structural mechanisms of PRC1-mediated interplay between gene repression and activation

Yu, Y, Cai, D, Zhang, Y.Z, Huang, J.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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