ISDA: 9V9C

Deposition Date 2025-05-30

Release Date 2026-04-08

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9V9C

Keywords:

PROTEIN FIBRIL

Title:

Cryo-EM structure of human TNFR1 DD filament

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.62 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tumor necrosis factor recepto
Gene (Uniprot):TNFRSF1A
Chain IDs:A, B, C, D, E, F, G (auth: I), H (auth: L), I (auth: O), J (auth: R), K (auth: G), L (auth: J), M, N (auth: P), O (auth: S), P (auth: H), Q (auth: K), R (auth: N), S (auth: Q), T
Chain Length:114
Number of Molecules:20
Biological Source:Homo sapiens

UniProt ID:P19438 Pfam ID:PF00531

Ligand Molecules

Primary Citation

Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome.

Liu, J, Zhao, J, Gao, J, Zhao, K, Han, Y, Yang, J, Li, Z, Ye, J, Sun, Z, Wang, F, Liu, X, Li, Z, Ji, S, Liu, B, Liu, C, Zhang, Y, Yuan, J, Chou, J.J.Show

Nature ? ? ? (2026)

PMID: 41922760 DOI: 10.1038/s41586-026-10304-1

Primary Citation of related structures

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