ISDA: 9V5U

Deposition Date 2025-05-26

Release Date 2026-05-06

Last Version Date 2026-05-06

Entry Detail

PDB ID:

9V5U

Keywords:

ISOMERASE

Title:

PfDXR - Mn2+ - SHOK344 ternary complex

Biological Source:

Source Organism(s):

Plasmodium falciparum HB3 (Taxon ID: 137071)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.53 Å

R-Value Free:

0.19

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:1-deoxy-D-xylulose 5-phosphat
Gene (Uniprot):DXR
Chain IDs:A, B
Chain Length:488
Number of Molecules:2
Biological Source:Plasmodium falciparum HB3

UniProt ID:O96693 EC:1.1.1.267

Ligand Molecules

A1L9Z

GOL

Primary Citation

Reverse Fosmidomycin Analogs as Bisubstrate Inhibitors: Binding Mode Elucidation and Mechanistic Insights.

Hoefmann, S, Takada, S, Illarionov, B, Carvalho, L.P, Ozawa, S, Gangnus, T, Knak, T, Abdullaziz, M.A, Wladarz, N, Bacher, A, Sakamoto, Y, Burckhardt, B.B, Held, J, Fischer, M, Tanaka, N, Kurz, T.Show

J.Med.Chem. ? ? ? (2026)

Primary Citation of related structures

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