9V31 image
Deposition Date 2025-05-21
Release Date 2026-05-27
Last Version Date 2026-05-27
Entry Detail
PDB ID:
9V31
Keywords:
MEMBRANE PROTEIN/IMMUNE SYSTEM
Title:
Human claudin 18.2 (dimer form) in complex with the Fab fragment of Osemitamab (TST001)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Komagataella pastoris, Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
4.40 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9V31 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform A2 of Claudin-18
Gene (Uniprot):CLDN18
Chain IDs:A, F (auth: B)
Chain Length:211
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P56856 Pfam ID:PF00822
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Fab of Osemitamab (TST001) -
Chain IDs:B (auth: H), D (auth: C)
Chain Length:249
Number of Molecules:2
Biological Source:Mus musculus
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Fab of Osemitamab (TST001) -
Chain IDs:C (auth: L), E (auth: D)
Chain Length:220
Number of Molecules:2
Biological Source:Mus musculus
Ligand Molecules
NA
Primary Citation
Recognition of human claudin 18.2 by therapeutic antibodies
To Be Published ? ? ? (?)
Primary Citation of related structures
9V31
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