ISDA: 9UZL

Deposition Date 2025-05-16

Release Date 2026-05-27

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9UZL

Keywords:

RIBOSOME

Title:

EMCV IRES captured on mammalian 40S ribosome with initiator tRNA and eIF2

Biological Source:

Source Organism(s):

Encephalomyocarditis virus (Taxon ID: 12104)
Oryctolagus cuniculus (Taxon ID: 9986)

Expression System(s):

Escherhicia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

5.01 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polyribonucleotide
Molecule:18S ribosomal RNA
Chain IDs:A (auth: 2)
Chain Length:1863
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Chain IDs:B (auth: A)
Chain Length:315
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Polymer Type:polypeptide(L)
Molecule:Eukaryotic translation initia
Chain IDs:C (auth: B)
Chain Length:485
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPSA
Chain IDs:D (auth: C)
Chain Length:295
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TLT8 Pfam ID:PF00318, PF16122

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS3A
Chain IDs:E (auth: D)
Chain Length:264
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TN72 Pfam ID:PF01015

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Chain IDs:F (auth: E)
Chain Length:226
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS3
Chain IDs:G (auth: F)
Chain Length:243
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TNM3 Pfam ID:PF07650, PF00189 EC:4.2.99.18

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS4X
Chain IDs:H (auth: G)
Chain Length:263
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TK17 Pfam ID:PF08071, PF00900, PF00467, PF16121

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS5
Chain IDs:I (auth: H)
Chain Length:204
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TFM5 Pfam ID:PF00177

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS6
Chain IDs:J (auth: I)
Chain Length:249
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TM55 Pfam ID:PF01092

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS7
Chain IDs:K (auth: J)
Chain Length:194
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SVB0 Pfam ID:PF01251

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS8
Chain IDs:L (auth: K)
Chain Length:206
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TJW1 Pfam ID:PF01201

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS9
Chain IDs:M (auth: L)
Chain Length:194
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:B7NZS8 Pfam ID:PF00163, PF01479

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS10
Chain IDs:N (auth: M)
Chain Length:225
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0AAG1W9A6 Pfam ID:PF03501

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS11
Chain IDs:O (auth: N)
Chain Length:158
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TRM4 Pfam ID:PF16205, PF00366

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS12
Chain IDs:P (auth: O)
Chain Length:132
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SFR8 Pfam ID:PF01248

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS13
Chain IDs:Q (auth: P)
Chain Length:151
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SP51 Pfam ID:PF08069, PF00312

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein S14
Chain IDs:R (auth: Q)
Chain Length:168
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0AAA9WYR1 Pfam ID:PF00411

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS15
Chain IDs:S (auth: R)
Chain Length:145
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1U0Q2 Pfam ID:PF00203

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS16
Chain IDs:T (auth: S)
Chain Length:146
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SGX4 Pfam ID:PF00380

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS17
Chain IDs:U (auth: T)
Chain Length:135
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TU13 Pfam ID:PF00833

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS18
Chain IDs:V (auth: U)
Chain Length:152
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TPG3 Pfam ID:PF00416

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS19
Chain IDs:W (auth: V)
Chain Length:141
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TN62 Pfam ID:PF01090

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS20
Chain IDs:X (auth: W)
Chain Length:119
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SIZ2 Pfam ID:PF00338

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS21
Chain IDs:Y (auth: X)
Chain Length:82
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TM82 Pfam ID:PF01249

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS15A
Chain IDs:Z (auth: Y)
Chain Length:130
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TG89 Pfam ID:PF00410

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS23
Chain IDs:AA (auth: Z)
Chain Length:143
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SZ47 Pfam ID:PF00164

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S24
Chain IDs:BA (auth: a)
Chain Length:126
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TS40 Pfam ID:PF01282

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS26
Chain IDs:CA (auth: b)
Chain Length:115
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TFE8 Pfam ID:PF01283

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS27
Chain IDs:DA (auth: c)
Chain Length:84
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TZ76 Pfam ID:PF01667

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS28
Chain IDs:EA (auth: d)
Chain Length:64
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1TIB4 Pfam ID:PF01200

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS29
Chain IDs:FA (auth: e)
Chain Length:56
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1U7M4 Pfam ID:PF00253

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin-ribosomal protein e
Gene (Uniprot):RPS27A
Chain IDs:GA (auth: f)
Chain Length:156
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SK22 Pfam ID:PF00240, PF01599

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RACK1
Chain IDs:HA (auth: g)
Chain Length:317
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1SJB4 Pfam ID:PF00400

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Chain IDs:IA (auth: h)
Chain Length:125
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):FAU
Chain IDs:JA (auth: i)
Chain Length:59
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:G1T8A2 Pfam ID:PF04758

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPL41
Chain IDs:KA (auth: l)
Chain Length:25
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

UniProt ID:A0A087WNH4 Pfam ID:PF05162

Polymer Type:polyribonucleotide
Molecule:Initiator tRNA
Chain IDs:LA (auth: y)
Chain Length:75
Number of Molecules:1
Biological Source:Oryctolagus cuniculus

Polymer Type:polyribonucleotide
Molecule:Encephalomyocarditis viral IR
Chain IDs:MA (auth: z)
Chain Length:93
Number of Molecules:1
Biological Source:Encephalomyocarditis virus

Ligand Molecules

Primary Citation

Structural insights into the recruitment of viral type 2 IRES to ribosomal preinitiation complex for protein synthesis.

Das, D, Hussain, T.Show

Elife 14 ? ? (2026)

PMID: 42345371 DOI: 10.7554/eLife.107788

Primary Citation of related structures

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