ISDA: 9UVW

Deposition Date 2025-05-11

Release Date 2026-05-06

Last Version Date 2026-05-06

Entry Detail

PDB ID:

9UVW

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of Vasopressin receptor 2 (V2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with tolvaptan, focused on receptor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Escherichia coli (Taxon ID: 562)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.89 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Vasopressin V2 receptor,Solub
Gene (Uniprot):cybC, AVPR2
Mutagens:M243W/H338I/R342L
Chain IDs:A
Chain Length:486
Number of Molecules:1
Biological Source:Homo sapiens, Escherichia coli

UniProt ID:P30518,P0ABE7 Pfam ID:PF00001

Ligand Molecules

A1IT8

Primary Citation

A Rapid and Universal Pipeline for High-Resolution GPCR Structure Determination through <em>In Silico</em> Construct Optimization and de novo Protein Design

Kojima, A, Kawakami, K, Kobayashi, N, Kobayashi, K, Matsui, T.E, Uemoto, K, Gu, Y, Fukuda, M, Kato, H.E.Show

Biorxiv ? ? ? (2026)

DOI: 10.64898/2026.04.02.716066

Primary Citation of related structures

Feedback Form