9UVV image
Deposition Date 2025-05-11
Release Date 2026-05-06
Last Version Date 2026-05-06
Entry Detail
PDB ID:
9UVV
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of Vasopressin receptor 2 (V2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with tolvaptan
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Escherichia coli (Taxon ID: 562)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Homo sapiens, Cricetulus griseus
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.02 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9UVV validation report missing
Macromolecular Entities
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Vasopressin V2 receptor,Solub
Gene (Uniprot):cybC, AVPR2
Mutagens:M243W/H338I/R342L
Chain IDs:A
Chain Length:486
Number of Molecules:1
Biological Source:Homo sapiens, Escherichia coli
UniProt ID:P30518,P0ABE7 Pfam ID:PF00001
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Heavy chain of anti-BRIL SRP2
Chain IDs:C (auth: H)
Chain Length:290
Number of Molecules:1
Biological Source:Mus musculus
UniProt ID:9UVV
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Light chain of anti-BRIL SRP2
Chain IDs:B (auth: L)
Chain Length:235
Number of Molecules:1
Biological Source:Mus musculus
UniProt ID:9UVV
Ligand Molecules
A1IT8
Primary Citation
A Rapid and Universal Pipeline for High-Resolution GPCR Structure Determination through <em>In Silico</em> Construct Optimization and de novo Protein Design
Biorxiv ? ? ? (2026)
DOI: 10.64898/2026.04.02.716066
Primary Citation of related structures
9UVV
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