9UPU image
Deposition Date 2025-04-29
Release Date 2026-04-29
Last Version Date 2026-04-29
Entry Detail
PDB ID:
9UPU
Keywords:
SIGNALING PROTEIN/IMMUNE SYSTEM
Title:
Cryo-EM strucutre of CXCR4 complexed with agonist SDV1a
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Escherichia coli (Taxon ID: 562)
Oplophorus gracilirostris (Taxon ID: 727944)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.80 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9UPU validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Chain IDs:C (auth: A)
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P63096
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:A (auth: B)
Chain Length:384
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62873
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:B (auth: C)
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P59768
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Stromal cell-derived factor 1
Gene (Uniprot):CXCL12
Chain IDs:E (auth: J)
Chain Length:8
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P48061
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Soluble cytochrome b562,C-X-C
Gene (Uniprot):cybC, CXCR4
Chain IDs:F (auth: R)
Chain Length:648
Number of Molecules:1
Biological Source:Escherichia coli, Homo sapiens, Oplophorus gracilirostris
UniProt ID:P0ABE7,P61073,Q9GV45 EC:1.13.12.13
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:single-chain variable fragmen
Chain IDs:D (auth: S)
Chain Length:259
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:9UPU
Ligand Molecules
CLR
Primary Citation
The cryo-EM-delineated mechanism underlying mimicry of CXCR4 agonism enables widespread stem cell neuroprotection in a mouse model of ALS.
Biorxiv ? ? ? (2025)
PMID: 40672153 DOI: 10.1101/2025.07.08.663251
Primary Citation of related structures
9UPU
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