ISDA: 9UOH

Deposition Date 2025-04-25

Release Date 2026-03-04

Last Version Date 2026-03-04

Entry Detail

PDB ID:

9UOH

Keywords:

HYDROLASE

Title:

KRasG12C in complex with ASP2453

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.75 Å

R-Value Free:

0.25

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

H 3 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Chain IDs:A
Chain Length:170
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P01116 Pfam ID:PF00071

Ligand Molecules

A1L9E

GDP

SO4

Primary Citation

Discovery of ASP2453, a potent and orally bioavailable covalent inhibitor of KRAS G12C for the treatment of solid tumors

Imaizumi, T, Imanishi, M, Yamaki, S, Shimada, I, Satake, Y, Nigawara, T, Koike, T, Yamanaka, Y, Amano, Y, Mori, K, Nakayama, A, Nishizono, Y, Shimazaki, M, Nagashima, T, Kuramoto, K.Show

Results Chem 18 102799 ? (2025)

DOI: 10.1016/j.rechem.2025.102799

Primary Citation of related structures

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