ISDA: 9UGJ

Deposition Date 2025-04-12

Release Date 2026-02-18

Last Version Date 2026-09-02

Entry Detail

PDB ID:

9UGJ

Keywords:

HYDROLASE

Title:

Structure of SARM1 bound to SIR3-ADPR

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.85 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:NAD(+) hydrolase SARM1
Gene (Uniprot):SARM1
Chain IDs:A, B, C, D, E, F, G, H
Chain Length:0
Number of Molecules:8
Biological Source:Homo sapiens

UniProt ID:Q6SZW1 Pfam ID:PF07647, PF13676 EC:3.2.2.6,3.2.2.-

Ligand Molecules

A1EO4

Primary Citation

SARM1 activation promotes axonal degeneration via a two-step phase transition.

Zhang, W, Zhou, Q, Zhang, J, Wang, J, Wu, Q, Zheng, S, Wang, X.Show

Nat.Chem.Biol. 22 435 445 (2026)

PMID: 40846996 DOI: 10.1038/s41589-025-02009-9

Primary Citation of related structures

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