ISDA: 9UF8

Deposition Date 2025-04-10

Release Date 2025-09-10

Last Version Date 2026-07-01

Entry Detail

PDB ID:

9UF8

Keywords:

HYDROLASE

Title:

The cryo-EM structure of 26S proteasome-Midnolin complex in the MA state

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

4.32 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC2
Chain IDs:PA (auth: A)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P35998 Pfam ID:PF21236, PF00004, PF17862

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC1
Chain IDs:RA (auth: B)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62191 Pfam ID:PF16450, PF00004, PF17862

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC5
Chain IDs:SA (auth: C)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62195 Pfam ID:PF16450, PF00004, PF17862

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC4
Chain IDs:TA (auth: D)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P43686 Pfam ID:PF16450, PF00004, PF17862

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC6
Chain IDs:UA (auth: E)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62333 Pfam ID:PF16450, PF00004, PF17862

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC3
Chain IDs:B (auth: F)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P17980 Pfam ID:PF16450, PF00004, PF17862

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA6
Chain IDs:D (auth: G), Q (auth: g)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P60900 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA2
Chain IDs:F (auth: H), S (auth: h)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25787 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA4
Chain IDs:H (auth: I), O (auth: i)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25789 Pfam ID:PF10584, PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA7
Chain IDs:J, U (auth: j)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O14818 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA5
Chain IDs:L (auth: K), W (auth: k)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28066 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA1
Chain IDs:N (auth: L), Y (auth: l)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25786 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA3
Chain IDs:P (auth: M), AA (auth: m)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25788 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB6
Chain IDs:A (auth: N), CA (auth: n)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28072 Pfam ID:PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB7
Chain IDs:C (auth: O), EA (auth: o)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q99436 Pfam ID:PF00227, PF12465 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB3
Chain IDs:E (auth: P), GA (auth: p)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49720 Pfam ID:PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB2
Chain IDs:G (auth: Q), IA (auth: q)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49721 Pfam ID:PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB5
Chain IDs:I (auth: R), KA (auth: r)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28074 Pfam ID:PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB1
Chain IDs:K (auth: S), MA (auth: s)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P20618 Pfam ID:PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB4
Chain IDs:M (auth: T), OA (auth: t)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28070 Pfam ID:PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD1
Chain IDs:R (auth: U)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q99460 Pfam ID:PF21505, PF01851, PF13646, PF18004 EC:5.6.1.5

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD3
Chain IDs:T (auth: V)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O43242 Pfam ID:PF01399, PF08375, PF25573

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD12
Chain IDs:V (auth: W)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O00232 Pfam ID:PF22241, PF01399, PF18098

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD11
Chain IDs:X
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O00231 Pfam ID:PF18055, PF01399, PF18503

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD6
Chain IDs:Z (auth: Y)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15008 Pfam ID:PF10602, PF01399, PF21154

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD7
Chain IDs:BA (auth: Z)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P51665 Pfam ID:PF01398, PF13012

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD13
Chain IDs:DA (auth: a)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9UNM6 Pfam ID:PF22037, PF01399

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD4
Chain IDs:FA (auth: b)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P55036 Pfam ID:PF13519, PF02809

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD14
Chain IDs:HA (auth: c)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O00487 Pfam ID:PF01398, PF23594 EC:3.4.19.-

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD8
Chain IDs:JA (auth: d)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P48556 Pfam ID:PF10075

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome complex subuni
Gene (Uniprot):SEM1
Chain IDs:LA (auth: e)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P60896 Pfam ID:PF05160

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD2
Chain IDs:NA (auth: f)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13200 Pfam ID:PF17781, PF01851, PF18051

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Midnolin
Gene (Uniprot):MIDN
Chain IDs:QA (auth: u)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q504T8 Pfam ID:PF00240

Ligand Molecules