ISDA: 9UEE

Deposition Date 2025-04-08

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9UEE

Keywords:

BIOSYNTHETIC PROTEIN

Title:

Crystal structure of (R)-carbonyl reductase mutant I51L/Y61F/D147E from Candida Parapsilosis in complex with NAD

Biological Source:

Source Organism(s):

Candida parapsilosis (Taxon ID: 5480)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.50 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.21

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:(R)-specific carbonyl reducta
Gene (Uniprot):rCR
Mutagens:I51L,Y61F,D147E
Chain IDs:A, B, C, D
Chain Length:336
Number of Molecules:4
Biological Source:Candida parapsilosis

UniProt ID:A1X808 EC:1.1.1.184

Ligand Molecules

NAD

Primary Citation

Data-Driven Global Evolutionary Strategy Overcomes Multifunctional Trade-offs in Stereoselective Carbonyl Reductase Engineering

Gu, J, Su, X, Wang, J, Yu, Y, Li, Z, Mu, W, Mu, W, Xu, Y, Nie, Y.Show

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