ISDA: 9U8X

Deposition Date 2025-03-26

Release Date 2026-03-25

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9U8X

Keywords:

HYDROLASE

Title:

Crystal structure of KRAS-G12D/R68M mutant in complex with GDP

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.65 Å

R-Value Free:

0.25

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 63

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Mutagens:G12D,R68M
Chain IDs:A
Chain Length:189
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2

Ligand Molecules

GDP

Primary Citation

Molecule Mechanisms of KRAS Secondery Mutation Conferred Resistance of MRTX1133

Zhang, X.L, Zhang, X.Y, Zhang, Y.Z, Bai, F.Show

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