ISDA: 9U8K

Deposition Date 2025-03-26

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9U8K

Keywords:

IMMUNE SYSTEM

Title:

Structure of ASC-PYD filament from condensates

Biological Source:

Source Organism(s):

human gammaherpesvirus 4 (Taxon ID: 10376)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.70 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Apoptosis-associated speck-li
Gene (Uniprot):Pycard
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, AA (auth: a1), BA (auth: b1), CA (auth: c1), DA (auth: d1), EA (auth: e1), FA (auth: f1), GA (auth: g1), HA (auth: h1), IA (auth: i1), JA (auth: j1), KA (auth: k1), LA (auth: l1), MA (auth: m1)
Chain Length:105
Number of Molecules:39
Biological Source:human gammaherpesvirus 4

UniProt ID:Q9EPB4 Pfam ID:PF02758

Ligand Molecules

Primary Citation

DNA-triggered AIM2 condensation orchestrates immune activation and regulation.

Li, Q, Geng, X, Yan, H, Li, Z, Shi, M, Zhu, Z, Niu, T, Zhao, C, Shu, K, Gao, Y, Feng, H, Liu, S, Jiang, Q, Bu, P, Li, D, Gao, P.Show

Protein Cell ? ? ? (2026)

PMID: 41883156 DOI: 10.1093/procel/pwag024

Primary Citation of related structures

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