ISDA: 9U4E

Deposition Date 2025-03-19

Release Date 2025-09-24

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9U4E

Keywords:

IMMUNE SYSTEM

Title:

Cryo-EM structure of the human CRP-CPS23F complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.78 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:C-reactive protein
Gene (Uniprot):CRP
Chain IDs:A, B, C, D, E
Chain Length:224
Number of Molecules:5
Biological Source:Homo sapiens

UniProt ID:P02741 Pfam ID:PF00354

Ligand Molecules

Primary Citation

C-reactive protein is a broad-spectrum capsule-binding receptor for hepatic capture of blood-borne bacteria.

Chen, D, Hu, J, Zhu, M, Xie, Y, Yao, H, An, H, Meng, Y, Wang, J, Huang, X, Liu, Y, Shao, Z, Xiang, Y, Qi, J, Gao, G.F, Zhang, J.R.Show

EMBO J. 44 7364 7394 (2025)

PMID: 41214213 DOI: 10.1038/s44318-025-00623-w

Primary Citation of related structures

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