9U19 image
Deposition Date 2026-01-29
Release Date 2026-03-11
Last Version Date 2026-03-11
Entry Detail
PDB ID:
9U19
Keywords:
Title:
Crystal structure of the NKX2.1 homeodomain in complex with a 12-bp DNA duplex containing a CACG motif variant
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Method Details:
Experimental Method:
Resolution:
1.18 Å
R-Value Free:
0.21
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
C 1 2 1
Macromolecular Entities
Polymer Type:polydeoxyribonucleotide
Molecule:CACG-containing 12bp forward
Chain IDs:A, D
Chain Length:12
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polydeoxyribonucleotide
Molecule:12bp reverse complementary
Chain IDs:B, E
Chain Length:12
Number of Molecules:2
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Homeobox protein Nkx-2.1
Gene (Uniprot):NKX2-1
Chain IDs:C, F
Chain Length:59
Number of Molecules:2
Biological Source:Homo sapiens
Ligand Molecules
Primary Citation
Quantification of the effects of single nucleotide variants in NKX2.1 transcription factor binding sites
Biorxiv ? ? ? (2026)
DOI: 10.64898/2026.02.27.708450
Primary Citation of related structures
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