ISDA: 9TYV

Deposition Date 2026-01-21

Release Date 2026-10-07

Last Version Date 2026-10-07

Entry Detail

PDB ID:

9TYV

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of human TMEM45B with a bound GM3 (18:1;O2/24:1)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.82 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transmembrane protein 45B
Gene (Uniprot):TMEM45B
Chain IDs:A, B, C, D
Chain Length:275
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q96B21 Pfam ID:PF04819

Ligand Molecules

A1KB5

CLR

UNX

Primary Citation

Cryo-EM structure of human TMEM45B with a bound GM3 (18:1;O2/24:1).

Grieben, M, Inderhees, J, Ebersberger, N.Show

J.Struct.Biol. 218 108376 108376 (2026)

PMID: 42785650 DOI: 10.1016/j.jsb.2026.108376

Abstact

The orphan transmembrane protein 45B (TMEM45B) has been reported to be involved in mechanical pain hypersensitivity, antiviral processes, and cancer. The structure of human TMEM45B with bound monosialodihexosylganglioside (GM3, 18:1;O2/24:1), presented here, determined by single-particle cryo-electron microscopy (cryo-EM) to 2.8 A, reveals a homotetrameric assembly of seven-transmembrane-helix protomers. The first six transmembrane helices from each protomer create a central hydrophobic tunnel that accommodates metal ions and the C24:1 fatty acid component of the ganglioside GM3.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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