ISDA: 9TXV

Deposition Date 2026-01-16

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9TXV

Keywords:

TRANSFERASE

Title:

Catalytic domain of human tankyrase 2 in complex with a dual-site inhibitor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.90 Å

R-Value Free:

0.25

R-Value Work:

0.19

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Poly [ADP-ribose] polymerase
Gene (Uniprot):TNKS2
Chain IDs:A, B (auth: C)
Chain Length:170
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9H2K2 Pfam ID:PF00644 EC:2.4.2.30,2.4.2.-

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Poly [ADP-ribose] polymerase
Gene (Uniprot):TNKS2
Chain IDs:C (auth: B), D
Chain Length:48
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9H2K2 Pfam ID:PF00644 EC:2.4.2.30,2.4.2.-

Ligand Molecules