ISDA: 9TWU

Deposition Date 2026-01-15

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

9TWU

Keywords:

RNA BINDING PROTEIN

Title:

Complex of E. coli leucyl-tRNA synthetase AN3365-resistant mutant P339L bound to tRNA(leu)

Biological Source:

Source Organism(s):

Escherichia coli (Taxon ID: 562)

Expression System(s):

Escherichia coli, In vitro transcription vector pt7-fluc(deltai)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.63 Å

R-Value Free:

0.30

R-Value Work:

0.23

R-Value Observed:

0.24

Space Group:

P 1 21 1

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Leucine--tRNA ligase
Mutagens:P339L
Chain IDs:A
Chain Length:880
Number of Molecules:1
Biological Source:Escherichia coli

Polymer Type:polyribonucleotide
Molecule:tRNA(leu)
Chain IDs:B
Chain Length:87
Number of Molecules:1
Biological Source:Escherichia coli

Ligand Molecules

A1JX6

Primary Citation

Mechanisms of Resistance to an Antibiotic Targeting Bacterial Leucyl-tRNA Synthetase

Muller, B, Fries, F, Huber, A.L, Risch, T, Mohamadyar-Toupkanlou, F, Hoffmann, G, Dulic, M, Herrmann, J, Guic Sovulj, I, Muller, R, Palencia, A.Show

Nat Commun ? ? ? (2026)

Primary Citation of related structures

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