9TWB image
Deposition Date 2026-01-14
Release Date 2026-08-05
Last Version Date 2026-08-05
Entry Detail
PDB ID:
9TWB
Keywords:
SIGNALING PROTEIN
Title:
Crystal structure of BRAF(val600):MEK1(pS222) complex with asymmetric dimer interface bound to ADP
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.45 Å
R-Value Free:
0.26
R-Value Work:
0.21
Space Group:
P 21 21 21
9TWB validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dual specificity mitogen-acti
Gene (Uniprot):MAP2K1
Chain IDs:A, D
Chain Length:333
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q02750 Pfam ID:PF00069 EC:2.7.12.2
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):BRAF
Chain IDs:B (auth: C), C (auth: B)
Chain Length:282
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P15056 Pfam ID:PF07714 EC:2.7.10.2
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
SEP A SER modified residue
Ligand Molecules
ADP
CA
GOL
NA
Primary Citation
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer.
Mol.Cell ? ? ? (2026)
PMID: 42480522 DOI: 10.1016/j.molcel.2026.06.039
Primary Citation of related structures
9TWB
Feedback Form
Name
Email
Institute
Feedback