9TPW image
Deposition Date 2025-12-18
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9TPW
Keywords:
TRANSFERASE
Title:
cryo-ET structure of mTOR complex 2 on a PIP2-containing membrane
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
6.40 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SUBTOMOGRAM AVERAGING
9TPW validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):MTOR
Chain IDs:A, B
Chain Length:2590
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P42345 Pfam ID:PF11865, PF02259, PF23593, PF08771, PF00454, PF02260
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Target of rapamycin complex s
Gene (Uniprot):MLST8
Chain IDs:C, D
Chain Length:326
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q9BVC4 Pfam ID:PF00400
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Rapamycin-insensitive compani
Gene (Uniprot):RICTOR
Chain IDs:E, F
Chain Length:1734
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q6R327 Pfam ID:PF14664, PF14666, PF14663, PF14668, PF14665
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Target of rapamycin complex 2
Gene (Uniprot):MAPKAP1
Chain IDs:G, H
Chain Length:522
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q9BPZ7 Pfam ID:PF05422, PF16978, PF25322, PF16979
Ligand Molecules
ZN
Primary Citation
Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop
Biorxiv ? ? ? (2026)
DOI: 10.64898/2026.01.08.698367
Primary Citation of related structures
9TPW
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