9TPH image
Deposition Date 2025-12-18
Release Date 2026-04-15
Last Version Date 2026-04-15
Entry Detail
PDB ID:
9TPH
Keywords:
CELL CYCLE
Title:
Survivin 1-127 in complex with a molecular tweezer-Histone-H3-peptide conjugate
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.00 Å
R-Value Free:
0.26
R-Value Work:
0.21
R-Value Observed:
0.21
Space Group:
C 1 2 1
9TPH validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Baculoviral IAP repeat-contai
Gene (Uniprot):BIRC5
Chain IDs:A, B
Chain Length:126
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:O15392 Pfam ID:PF00653
Polymer Type:polypeptide(L)
Molecule:Histone-H3-peptide conjugated
Chain IDs:C, D
Chain Length:6
Number of Molecules:2
Biological Source:synthetic construct
Ligand Molecules
A1JXR
CA
ZN
Primary Citation
Molecular tweezer-peptide conjugates disrupt the protein-protein interaction between survivin and histone H3 essential in mitosis.
Beilstein J Org Chem 22 557 567 (2026)
PMID: 41929663 DOI: 10.3762/bjoc.22.41
Primary Citation of related structures
9TPH
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