ISDA: 9TN0

Deposition Date 2025-12-15

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

9TN0

Keywords:

TRANSFERASE

Title:

Akt1 mutant in complex with the 1-propyl 1,5-substituted pyrazole containing compound and EG

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.40 Å

R-Value Free:

0.23

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:RAC-alpha serine/threonine-pr
Gene (Uniprot):AKT1
Chain IDs:A
Chain Length:445
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P31749 Pfam ID:PF00169, PF00069, PF00433 EC:2.7.11.1

Ligand Molecules

A1JW1

EDO

Primary Citation

Isoform-Selective Targeting of Akt Through Covalent Allosteric Inhibition.

D'Angelo, G.D, Pervanidis, K.A, Athanasiadis, I, Lukianchikov, V, Scrima, A, Depta, L, Stier, S, Muller, M.P, Farin, H.F, Quambusch, L, Rauh, D.Show

Angew.Chem.Int.Ed.Engl. ? e3567206 e3567206 (2026)

PMID: 42704227 DOI: 10.1002/anie.3567206

Primary Citation of related structures

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