ISDA: 9TM3

Deposition Date 2025-12-11

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9TM3

Keywords:

TRANSFERASE

Title:

Monoclinic crystal structure of protein kinase CK2 catalytic subunit CK2alpha' (CSNK2A2 gene product) in complex with the indenoindole-precursor compound JC0151

Biological Source:

Source Organism(s):

Escherichia coli (Taxon ID: 562)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.20 Å

R-Value Free:

0.17

R-Value Work:

0.13

R-Value Observed:

0.14

Space Group:

P 1 21 1

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Casein kinase II subunit alph
Mutagens:C336S
Chain IDs:A, B
Chain Length:364
Number of Molecules:2
Biological Source:Escherichia coli

Ligand Molecules

A1JSZ

NIO

Primary Citation

Targeting Human Protein Kinase CK2 by a Library of Indeno[1,2-b]Indoles: Contribution of Thermal Shift Assay to Pre-Screening and Co-Crystallization to Post-Screening.

Guimaraes, M.M, Werner, C, Leroy, B, Charles, J, Guillon, J, Pinaud, N, Mularoni, A, Jean-Baptiste, M, Ximenes, P, Gast, A, Prinz, H, Aichele, D, Goncalves, A.G, Marminon, C, Bouaziz, Z, Jose, J, Delcros, J.G, Niefind, K, Le Borgne, M.Show

Arch Pharm 359 e70312 e70312 (2026)

PMID: 42544794 DOI: 10.1002/ardp.70312

Primary Citation of related structures

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