9TLU image
Deposition Date 2025-12-11
Release Date 2026-08-19
Last Version Date 2026-08-19
Entry Detail
PDB ID:
9TLU
Keywords:
DE NOVO PROTEIN
Title:
De novo designed single-chain antiparallel coiled-coil hairpin with binding site for BCL-xL, Sc-apCC-2-BCL-xL-3 in complex with BCL-xL
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli 'bl21-gold(de3)plyss ag'
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.99 Å
R-Value Free:
0.32
R-Value Work:
0.27
R-Value Observed:
0.27
Space Group:
P 61
9TLU validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Bcl-2-like protein 1
Mutagens:27_80del
Chain IDs:A (auth: B), B (auth: A)
Chain Length:153
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Sc-apCC-2-BCL-xL-3
Chain IDs:C, D
Chain Length:75
Number of Molecules:2
Biological Source:synthetic construct
Ligand Molecules
NA
Primary Citation
De Novo-Designed Bifunctional
J.Am.Chem.Soc. ? ? ? (2026)
DOI: 10.1021/jacs.6c07593
Primary Citation of related structures
9TLU
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