9TLU image
Deposition Date 2025-12-11
Release Date 2026-08-19
Last Version Date 2026-09-02
Entry Detail
PDB ID:
9TLU
Keywords:
Title:
De novo designed single-chain antiparallel coiled-coil hairpin with binding site for BCL-xL, Sc-apCC-2-BCL-xL-3 in complex with BCL-xL
Biological Source:
Source Organism(s):
Method Details:
Experimental Method:
Resolution:
2.99 Å
R-Value Free:
0.32
R-Value Work:
0.27
R-Value Observed:
0.27
Space Group:
P 61
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Bcl-2-like protein 1
Gene (Uniprot):BCL2L1
Mutagens:27_80del
Chain IDs:A (auth: B), B (auth: A)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Sc-apCC-2-BCL-xL-3
Chain IDs:C, D
Chain Length:0
Number of Molecules:2
Biological Source:synthetic construct
Ligand Molecules
Primary Citation
De Novo-Designed Bifunctional Proteins for Targeted Protein Degradation.
J.Am.Chem.Soc. 148 34311 34319 (2026)
PMID: 42619090 DOI: 10.1021/jacs.6c07593
Primary Citation of related structures
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