9TLS image
Deposition Date 2025-12-11
Release Date 2026-08-19
Last Version Date 2026-09-02
Entry Detail
PDB ID:
9TLS
Keywords:
DE NOVO PROTEIN
Title:
De novo designed single-chain antiparallel coiled-coil hairpin with binding site for KLHL20, Sc-apCC-2-KLHL20-3
Biological Source:
Source Organism(s):
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli 'bl21-gold(de3)plyss ag'
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.45 Å
R-Value Free:
0.21
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
P 1 21 1
9TLS validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sc-apCC-2-KLHL20-3
Chain IDs:A, B, C
Chain Length:78
Number of Molecules:3
Biological Source:synthetic construct
Ligand Molecules
GOL
IPA
Primary Citation
De Novo-Designed Bifunctional Proteins for Targeted Protein Degradation.
J.Am.Chem.Soc. 148 34311 34319 (2026)
PMID: 42619090 DOI: 10.1021/jacs.6c07593
Primary Citation of related structures
9TLS
Feedback Form
Name
Email
Institute
Feedback