9TLM image
Deposition Date 2025-12-11
Release Date 2026-08-19
Last Version Date 2026-09-02
Entry Detail
PDB ID:
9TLM
Keywords:
DE NOVO PROTEIN
Title:
De Novo designed single-chain antiparallel coiled-coil hairpin with binding site for MCL-1, Sc-apCC-2-MCL-1-1
Biological Source:
Source Organism(s):
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli 'bl21-gold(de3)plyss ag'
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.80 Å
R-Value Free:
0.26
R-Value Work:
0.24
R-Value Observed:
0.24
Space Group:
P 65 2 2
9TLM validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sc-apCC-2-MCL-1-1
Chain IDs:A
Chain Length:75
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
GOL
Primary Citation
De Novo-Designed Bifunctional Proteins for Targeted Protein Degradation.
J.Am.Chem.Soc. 148 34311 34319 (2026)
PMID: 42619090 DOI: 10.1021/jacs.6c07593
Primary Citation of related structures
9TLM
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