ISDA: 9TFM

Deposition Date 2025-11-27

Release Date 2026-07-15

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9TFM

Keywords:

TRANSFERASE

Title:

KIT kinase domain in complex with a 7-methoxyquinazolin-6-ol-based compound (45)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.10 Å

R-Value Free:

0.22

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Mast/stem cell growth factor
Mutagens:I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D
Chain IDs:A, B
Chain Length:327
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

A1JVR

Primary Citation

Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST.

Schulz, T, Beerbaum, M, Scrima, A, Jantzen, H, Teuber, A, Muhlenberg, T, Ebel, L, Garcia-Fossa, F, George, A, Berner, N, Weisner, J, Muller, M.P, Wilhelm, S, Sievers, S, Bauer, S, Rauh, D.Show

Nat Commun 17 ? ? (2026)

PMID: 42562826 DOI: 10.1038/s41467-026-76340-7

Primary Citation of related structures

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