ISDA: 9TFM

Deposition Date 2025-11-27

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9TFM

Keywords:

TRANSFERASE

Title:

KIT kinase domain in complex with a 7-methoxyquinazolin-6-ol-based compound (45)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.10 Å

R-Value Free:

0.22

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mast/stem cell growth factor
Gene (Uniprot):KIT
Mutagens:I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D
Chain IDs:A, B
Chain Length:327
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P10721 Pfam ID:PF07714 EC:2.7.10.1

Ligand Molecules

A1JVR

Primary Citation

Structure-based Scaffold Hopping Reveals Strategies to Overcome Oncogenic KIT and PDGFRA Mutation-Driven Drug-Resistance in GIST

Schulz, T, Beerbaum, M, Scrima, A, Jantzen, H, Teuber, A, Muehlenberg, T, Garcia-Fossa, F, Weisner, J, Mueller, M.P, Sievers, S, Bauer, S, Rauh, D.Show

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Primary Citation of related structures

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