9TD2 image
Deposition Date 2025-11-22
Release Date 2026-06-10
Last Version Date 2026-06-10
Entry Detail
PDB ID:
9TD2
Keywords:
CELL ADHESION
Title:
Integrin AlphaIIbBeta3 bound to Fab of the anti-HPA-1a antibody 26.4
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Cricetulus griseus, Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.64 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9TD2 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Integrin alpha-IIb
Gene (Uniprot):ITGA2B
Chain IDs:A
Chain Length:993
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P08514 Pfam ID:PF01839, PF08441, PF20805, PF20806
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Integrin beta-3
Gene (Uniprot):ITGB3
Chain IDs:B
Chain Length:735
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P05106 Pfam ID:PF17205, PF00362, PF18372, PF23105, PF07974, PF07965
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Antibody 26.4 Fab heavy chain
Chain IDs:C (auth: H)
Chain Length:242
Number of Molecules:1
Biological Source:Homo sapiens
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Antibody 26.4 Fab light chain
Chain IDs:D (auth: L)
Chain Length:215
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
CA
MG
NAG
Primary Citation
High-resolution cryo-EM structure of integrin aIIbb3 in complex with a disease-causing maternal HPA-1a antibody that blocks integrin activation
To Be Published ? ? ? (?)
Primary Citation of related structures
9TD2
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