ISDA: 9TCB

Deposition Date 2025-11-21

Release Date 2026-01-28

Last Version Date 2026-01-28

Entry Detail

PDB ID:

9TCB

Keywords:

TRANSFERASE

Title:

Catalytic domain of human PARP15 in complex with BAD

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.90 Å

R-Value Free:

0.21

R-Value Work:

0.18

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein mono-ADP-ribosyltrans
Gene (Uniprot):PARP15
Chain IDs:A, B
Chain Length:200
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q460N3 Pfam ID:PF00644 EC:2.4.2.30

Ligand Molecules

DQV

NCA

Primary Citation

Dimerization of human PARP15 is required for NAD+ binding and automodification

Tuovinen, A, Paakkonen, J, Maksimainen, M.M, Hirschen, L, Hentila, H.I, Tauscher, M, Luscher, B, Vela-Rodriguez, C, Korn, P, Lehtio, L.Show

Biorxiv ? ? ? (2025)

DOI: 10.64898/2025.12.15.694324

Primary Citation of related structures

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