ISDA: 9TA7

Deposition Date 2025-11-18

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

9TA7

Keywords:

HYDROLASE

Title:

Crystal structure of Ap4A hydrolase (ApaH) from Pseudomonas aeruginosa in complex with ADP

Biological Source:

Source Organism(s):

Pseudomonas aeruginosa (Taxon ID: 287)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.55 Å

R-Value Free:

0.22

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Bis(5'-nucleosyl)-tetraphosph
Gene (Uniprot):apaH
Chain IDs:A, B
Chain Length:286
Number of Molecules:2
Biological Source:Pseudomonas aeruginosa

UniProt ID:Q9I5U7 Pfam ID:PF00149 EC:3.6.1.41

Ligand Molecules

ADP

Primary Citation

Structural and functional insights into Pseudomonas aeruginosa ApaH, a diadenosine tetraphosphatase crucial for bacterial virulence.

Pistoia, G, Cervoni, M, Catalano, F, Troilo, F, Guidi, F, Comparini, E, Mignogna, G, Travaglini-Allocatelli, C, Giuffre, A, Coluccia, A, Imperi, F, Di Matteo, A, Giardina, G.Show

Protein Sci. 35 e70781 e70781 (2026)

PMID: 42640267 DOI: 10.1002/pro.70781

Primary Citation of related structures

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