9T8D image
Deposition Date 2025-11-12
Release Date 2026-09-09
Last Version Date 2026-09-09
Entry Detail
PDB ID:
9T8D
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of EA-RK-110-bound D3 dopamine receptor
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Escherichia coli (Taxon ID: 562)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Spodoptera frugiperda, Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.60 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9T8D validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:BAG2 anti-BRIL Fab Heavy chai
Chain IDs:B (auth: H)
Chain Length:229
Number of Molecules:1
Biological Source:synthetic construct
Polymer Type:polypeptide(L)
Molecule:BAG2 anti-BRIL Fab Light chai
Chain IDs:C (auth: L)
Chain Length:215
Number of Molecules:1
Biological Source:synthetic construct
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:D(3) dopamine receptor,Solubl
Gene (Uniprot):DRD3, cybC
Chain IDs:A (auth: R)
Chain Length:432
Number of Molecules:1
Biological Source:Homo sapiens, Escherichia coli
UniProt ID:P35462,P0ABE7 Pfam ID:PF00001
Ligand Molecules
A1JUJ
Primary Citation
The structure of the dopamine D3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology
Sci Adv 12 ? ? (2026)
DOI: 10.1126/sciadv.aef7411
Primary Citation of related structures
9T8D
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