9T73 image
Deposition Date 2025-11-10
Release Date 2026-08-05
Last Version Date 2026-08-26
Entry Detail
PDB ID:
9T73
Keywords:
OXIDOREDUCTASE
Title:
Tetrapodal ancestor of L-amino acid oxidase: I224A-Q225H-P361-PREGA-L367 mutant bound to phenylalanine
Biological Source:
Source Organism(s):
Tetrapoda (Taxon ID: 32523)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.82 Å
R-Value Free:
0.27
R-Value Work:
0.19
R-Value Observed:
0.20
Space Group:
P 1 21 1
9T73 validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Tetrapodal ancestor of L-amin
Chain IDs:A (auth: B), B (auth: A), C, D
Chain Length:485
Number of Molecules:4
Biological Source:Tetrapoda
Ligand Molecules
FAD
PHE
Primary Citation
Evolution of human IL4I1 preference for aromatic amino acids from a broad-specificity L-amino acid oxidase ancestor.
Proc.Natl.Acad.Sci.USA 123 e2608436123 e2608436123 (2026)
PMID: 42585003 DOI: 10.1073/pnas.2608436123
Primary Citation of related structures
9T73
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