ISDA: 9T5Q

Deposition Date 2025-11-05

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

9T5Q

Keywords:

CYTOSOLIC PROTEIN

Title:

LRR domain Structure of LRRC8A in complex with synthetic nanobody Sb4

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Homo sapiens, Escherichia coli mc1061

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.60 Å

R-Value Free:

0.22

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Volume-regulated anion channe
Chain IDs:A, C (auth: B)
Chain Length:415
Number of Molecules:2
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:Sb4
Chain IDs:B (auth: I), D (auth: C)
Chain Length:128
Number of Molecules:2
Biological Source:synthetic construct

Primary Citation

Structures of the volume-regulated anion channel LRRC8A/D in activating and inhibiting conditions

Lehmann, E.F, Deneka, D, Stierli, F, Rutz, S, Dutzler, R.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form